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Pathology
Small vessel vasculitis characterised by deposition of IgA in skin and kidneys
Aetiology
Commoner in young males, often preceded by URTI.is.
Signs
Purpura on legs & buttocks, arthralgia and abdominal pain. GI haemorrhage (often due to intussusception), haematuria
Symptoms
Abdominal pain, haematuria, musculoskeletal pain, rash
Investigations
Bloods: Raised IgA, ESR and CRP, FBC shows raised platelet count
Skin biopsy: IgA and C3 in blood vessel wall
Treatment
Conservative: Spontaneous recovery within 4 weeks
Medical: Analgesia for arthralgia
Prognosis
Excellent
Long-term complications are secondary to renal involvement.
Follow-up is required for 1 year to monitor renal function and blood pressure
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