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Pathology
Defective bone mineralisation of new bone. Childhood form known as Rickets
Aetiology
Vitamin D deficiency, hypophosphataemia, chronic renal failure, Fanconi syndrome, anti-convulsant therapy
Signs
Proximal myopathy, hypocalcaemia
Symptoms
Waddling gait, bone pain, bone deformity (genu valgum in children), dental problems
Investigations
Bloods: Reduced calcium, phosphate, 25-OH Vitamin D, Raised ALP
Imaging: X-rays show pseudofracture/Looser’s zones (radiolucent areas at
right angles to cortex), loss of cortical bone.Treatment
Vitamin D replacement, correct underlying pathology.
Prognosis
Good prognosis if detected and treated early
Secondary hyperparathyroidism, hypercalacemia, kidney stones
Key Facts
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Key Images
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Key References
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