AML is a malignant proliferation of haematopoietic precursor blast cells of non-lymphoid lineage

AML usually develops without a clear precipitant. 

Commonest leukaemia in adults

Gum hypertrophy, fleshy nodules, hypoxia, retinal haemorrhage, confusion, 

Lymphadenopathy, hepatomegaly, splenomegaly, lymphadenopathy, bone pain

Bloods: FBC shows pancytopaenia with circulating blast cells 

Blood Film – Auer Rods

Bone marrow aspirate – Hypercellular and increased number of blast cells

Cytogenetics: Screen for molecular mutations

Medical: Treat infections early, blood transfusion, chemotherapy, 

immunotherapy, stem cell transplantation

Variable depending on: age (<50 favourable), cytogenetic abnormalities, molecular genetic abnormalities, presenting blast count (<25 unfavourable), AML classification, preceding myelodysplasia (poor prognosis).

Infection, bleeding, organ damage, hair loss, GI toxicity, Infertility