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Pathology
Primary liver tumour which usually occurs in the presence of cirrhosis
Aetiology
Cirrhosis and Hepatitis B
Signs
Cirrhosis, Jaundice, Ascites, Hepatomegaly
Symptoms
Abdominal Pain, Weight Loss, Jaundice, Right upper quadrant pain, Malaise
Investigations
Bloods: FBC, U&E, Clotting, Raised alfa-fetoprotein
Imaging: Ultrasound Abdomen shows a liver lesion
Treatment
Medical: Chemotherapy, Radiofrequency ablation, percutaneous ethanol injection,
transarterial chemoembolization – tumour blood supply identified and
chemotherapy infused directly through this artery
Surgical: Liver resection or liver transplantation are curative
Prognosis
Median survival is 6 to 20 months. Resection increases 5 year survival to 40% and
transplantation increases 5 year survival to 75%
Biliary obstruction
Key Facts
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Key Images
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Key References
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