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Pathology

Enteroviral infection which has a predilection to affect the nervous system. Incubation 3-35 days.

Aetiology

Poliovirus (an enterovirus) is transmitted via faecal-oral route. Rare in communities where vaccine uptake is good, worldwide distribution. 

Signs

Neck stiffness, asymmetrical weakness.

Symptoms

Most infections are asymptomatic.
Paralytic polio: presents as viral meningitis. After fever subsides, secondary fever arises with onset of flaccid paralysis.  Recovery is variable over next 12-18 months.

Investigations

Microbiology: Virus isolation from faeces, throat swab, CSF, antibody titre 
  (rising titre to enterovirus).

Treatment

Conservative: Isolation of patient, bedrest, care of pressure areas, 
physiotherapy for paralysed limbs
Medical: Ventilatory support if respiratory muscle involvement,
NG feeding for bulbar paralysis
Vaccination of susceptible contacts

Prognosis

Poor prognosis; 60% mortality in bulbar poliomyelitis
Paralysis, aspiration pneumonia.

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