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Pathology
Endothelial damage triggers deposition of fibrin, which damages passing red blood cells causing:
Triad of: AKI, thrombocytopenia and haemolysis with red cell fragmentation
Aetiology
Post-infection: classically E. Coli 0157:H7 or Shigella dysenteriae
Signs
Pallor, petechiae, hypertension
Symptoms
Haematuria, bloody diarrhoea, vomiting, abdominal pain, oliguria, fatigue
Investigations
Bloods: FBC, U&E, Clotting, Blood film
Urine: Haematuria
Stool Culture: Assess for bacterial infection
Treatment
Supportive: IVI fluids, dialysis
Prognosis
5% mortality
CRF, hypertension
Key Facts
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Key Images
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Key References
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