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Pathology

A group of disorders which cause inflammation of the glomerulus.

Aetiology

Post Group A β-haemolytic streptococcal infection, haemolytic uraemic syndrome, IgA nephropathy, Goodpasture Syndrome .

Signs

Hypertension and oedema

Symptoms

May be asymptomatic. Oliguria, oedema, haematuria, arthralgia, myalgia, nausea 
and vomiting

Investigations

Bloods: FBC, U&E, blood cultures, ANA, ANCA, anti-GBM, C3 and C4
MSU: Urine dipstick and protein: creatinine ratio
Ultrasound: Renal ultrasound to assess for structural abnormalities
Renal Biopsy: Diagnostic

Treatment

Medical: Salt restriction, fluid monitoring, blood pressure control, 
thromboprophylaxis.

Prognosis

Adults: 60% resolve
Children: 90% resolve
Renal failure, pulmonary oedema and hypertensive encephalopathy

Key Facts

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Key Images

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Key References

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