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Pathology

Similar pathologically to alcoholic liver disease


Aetiology

Associated with diabetes, obesity, metabolic syndrome

Signs

Asymptomatic

Symptoms

Asymptomatic.

Investigations

Bloods: FBC, Lipids, Glucose and LFTs show AST:ALT ratio <1
Imaging: USS Abdomen may show a bright liver 
Liver Biopsy: Steatosis and Steatohepatitis. Mallory bodies common in non-
alcoholic steatohepatitis 

Treatment

Conservative: Lifestyle advice
Medical: Control hypertension and improve diabetic control

Prognosis

8–30% of developing fibrosis or cirrhosis after 10 years
Can progress to fibrosis then cirrhosis

Key Facts

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Key Images

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Key References

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