Reading Time:
Pathology
Bone marrow aplasia leading to pancytopenia
Aetiology
Idiopathic – Most cases
Hereditary - Fanconi Syndrome
Post Viral - Hepatitis A, B, C
Drug induced - Carbamazepine, busulfan
Radiation – Exposure to high doses of radiation
Signs
Pallor, bruising, increased respiratory rate
Symptoms
Shortness of breath, palpitations, chest pain, bleeding, easy bruising, recurrent
infections
Investigations
Bloods: FBC – pancytopenia
Blood Film: Reduction in number of visible cells
Bone Marrow Aspirate: Hypocellular Marrow
Treatment
Medical: Careful observation, blood transfusion, immunosuppressive therapy,
and bone marrow transplant in severe cases
Prognosis
Potential for cure with bone marrow transplant, immunosuppression may give
good results.
Progression to more severe disease, progression to acute leukaemia.
Development of paroxysmal nocturnal haemoglobinuria
Key Facts
Lorem ipsum dolor sit amet, sapien platea morbi dolor lacus nunc, nunc ullamcorper. Felis aliquet egestas vitae, nibh ante quis quis dolor sed mauris.
Key Images
Lorem ipsum dolor sit amet, sapien platea morbi dolor lacus nunc, nunc ullamcorper. Felis aliquet egestas vitae, nibh ante quis quis dolor sed mauris.
Key References
Lorem ipsum dolor sit amet, sapien platea morbi dolor lacus nunc, nunc ullamcorper. Felis aliquet egestas vitae, nibh ante quis quis dolor sed mauris.