Proteinuria > 3g/24 hours,
Hypoalbuminaemia < 30g/l and
Oedema also an associated hypercholestrolaemia.
Primary: Minimal change disease, membranous nephropathy, focal segmental
Secondary: Diabetes, SLE, amyloidosis, hypertension
Marked pitting oedema, ascites and pleural effusions
Swollen legs, weight gain, lethargy, shortness of breath.
loods: FBC, U&E, LFT’s, lipid profile glucose, myeloma screen, ANA
MSU: Urine dipstick and protein: creatinine ratio
Ultrasound: Renal ultrasound to assess for structural abnormalities
Renal Biopsy: Diagnostic
Medical: Loop diuretics, ACE inhibitors, statins.
Dependent on underlying cause and response to treatments; persistent heavy proteinuria is associated with progressive renal failure and worse outcomes.
Hypercoagulability, hyperlipidaemia, infection