Affects small to medium sized vessels.
Necrotising granuloma affecting vessels of lungs, GI tract and peripheral nerves
Associated with pANCA
3 distinct stages
1. Sinusitis and onset of allergies
2. Onset of acute asthma
3. Systemic involvement: skin purpura, GI upset, peripheral neuropathy.
Chest tightness, wheeze, Shortness of breath, sinusitis
Bloods: FBC shows eosinophilia, pANCA, CRP and ESRImaging: Chest X-ray shows eosinophilic lung deposits.
Medical: Steroids, immunosuppression
Poor prognosis and end organ damage