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Pathology

Nephrotic Syndrome with little changes seen on light microscopy. Most common cause of nephrotic syndrome in children.

Aetiology

Unknown aetiology.

Signs

Marked pitting oedema, ascites and pleural effusions

Symptoms

Swollen legs, weight gain, lethargy, shortness of breath.

Investigations

Bloods: FBC, U&E, LFT’s, lipid profile glucose, myeloma screen, ANA
MSU: Urine dipstick and protein: creatinine ratio
Renal Biopsy: Light microscopy shows no changes but electron microscopy 
show podocyte fusion

Treatment

Medical: Steroid therapy, immunosuppression

Prognosis

Adults: 70% resolve with steroids but are more likely to relapse
Children: 95% resolve with steroids – 33% have no further relapses with 33% having regular relapses

Key Facts

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Key Images

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Key References

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