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Pathology
Nephrotic Syndrome with little changes seen on light microscopy. Most common cause of nephrotic syndrome in children.
Aetiology
Unknown aetiology.
Signs
Marked pitting oedema, ascites and pleural effusions
Symptoms
Swollen legs, weight gain, lethargy, shortness of breath.
Investigations
Bloods: FBC, U&E, LFT’s, lipid profile glucose, myeloma screen, ANA
MSU: Urine dipstick and protein: creatinine ratio
Renal Biopsy: Light microscopy shows no changes but electron microscopy
show podocyte fusion
Treatment
Medical: Steroid therapy, immunosuppression
Prognosis
Adults: 70% resolve with steroids but are more likely to relapse
Children: 95% resolve with steroids – 33% have no further relapses with 33% having regular relapses
Key Facts
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Key Images
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Key References
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