Nephrotic Syndrome with little changes seen on light microscopy. Most common cause of nephrotic syndrome in children.
Marked pitting oedema, ascites and pleural effusions
Swollen legs, weight gain, lethargy, shortness of breath.
Bloods: FBC, U&E, LFT’s, lipid profile glucose, myeloma screen, ANA
MSU: Urine dipstick and protein: creatinine ratio
Renal Biopsy: Light microscopy shows no changes but electron microscopy
show podocyte fusion
Medical: Steroid therapy, immunosuppression
Adults: 70% resolve with steroids but are more likely to relapse
Children: 95% resolve with steroids – 33% have no further relapses with 33% having regular relapses