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Pathology
Deposition of IgA antibodies within the kidney leading to an immune reaction.
Aetiology
Unknown aetiology
Signs
Hypertension, microscopic haematuria, proteinuria are the commonest findings
Symptoms
Oliguria, peripheral oedema, Henoch-Schonlein purpura (non-blanching purpuric rash over legs and buttocks, abdominal pains can also be present)
Investigations
Bloods: Serum IgA, U&E – to monitor renal function
MSU: Urine dipstick and protein: creatinine ratio,
Renal Biopsy: Definitive investigation showing IgA and C3 deposits in renal
mesangium
Treatment
Medical: Steroids, Immunosuppressants, ACE inhibitors
Prognosis
A gradual deterioration in renal function over many years with about a third developing end stage renal failure
Hypertension and end stage renal failure.Key Facts
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Key Images
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Key References
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