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Pathology
Water soluble vitamin, found in pork, rice, beans and cereals
Role as enzyme co-factor
Aetiology
Alcohol excess
Signs
Beri Beri: Motor and sensory peripheral neuropathy resulting in pain and weakness,
can also present with CCF, ascites and peripheral oedema
Wernicke’s Encephalopathy: Confusion, nystagmus, ataxia and ophthalmoplegia,
almost always associated with alcohol excess
Korsakoff’s Syndrome: Chronic state due to Wernicke’s encephalopathy results in
impaired short term memory characterised by confabulat.Symptoms
Confusion, gait abnormalities, memory problems
Investigations
Clinical diagnosis
Treatment
Medical: IV thiamine and oral thiamine supplements
Prognosis
Beri Beri and Wernicke’s encephalopathy reverse with supplementation, Korsakoff’s syndrome is irreversible
Korsakoff’s syndrome is irreversible
Key Facts
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Key Images
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Key References
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