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Pathology
Chronic hepatitis of autoimmune origin
Aetiology
Unknown, association with other autoimmune diseases
Signs
Asymptomatic, jaundice
Symptoms
Lethargy, pruritus
Investigations
Bloods: LFTs show raised bilirubin and ALT
Auto-Antibody Screen: Anti-smooth muscle and Anti-nuclear (ANA) positive
Imaging: Ultrasound Abdomen may be normal, cirrhosis if advanced
Treatment
Medical: Steroids and immunosuppression with azathioprine
Complications: Cirrhosis, liver failure
Prognosis
50% of patients will die within 10 years of disease onset without treatment.
Cirrhosis, liver failure
Key Facts
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Key Images
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Key References
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