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Pathology
Inflammation of small-sized venules producing characteristic ulceration of skin, eyes and mucosa
Aetiology
HLA B51, commoner in Turkish/Iranian males
Signs
Arthralgia, thrombophlebitis, epididymitis, malaise, GI ulceration
Symptoms
Oral aphthous ulcers, skin lesions (papulo-pustules), uveitis/iritis, genital ulceration, pathergy reaction (papule >2mm 48hrs after skin needle-prick)
Investigations
Bloods: Raised ESR and CRP
Microbiology: Papule swabs are sterile
Treatment
Medical: Steroids, Cyclosporin, immunosuppression
Prognosis
Poor prognosis if delayed treatment
Optic atrophy, visual impairment
Key Facts
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Key Images
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Key References
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