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Pathology

Enthesitis with chronic inflammation, including cytokines particularly tumor necrosis factor-α leading to fibrosis and ossification at sites of enthesitis

Aetiology

Strong association with HLA-B27

Signs


Signs: Tenderness of the Sacro-Iliac joint or a limited spinal ROM. 
Kyphosis- Schober’s test is used to assess for limited spinal range of movement
Lung fibrosis, Achilles tendonitis, anterior uveitis, aortic regurgitation, anaemia, amyloidosis

Symptoms

Lower back pain, morning joint stiffness, malaise, sacroiliitis causing buttock pain

Investigations

Bloods: FBC, ESR, CRP and HLA-B27
Imaging: X-rays show sacroiliitis, syndesmophyte formation, vertebral fusion 
(bamboo spine), marginal erosion

Treatment

Conservative: Physiotherapy
Medical: Long term NSAIDs, DMARDs and Biological Therapy
Surgical: Osteotomy for kyphosis

Prognosis

Increased mortality compared to general population 
Amyloidosis, respiratory complications due to immobility of spine

Key Facts

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Key References

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