Antibody mediated disorder causing muscle weakness, loss of reflexes and autonomic dysfunction.
Antibodies interfere with calcium dependent acetylcholine release in presynaptic junction
Both muscle strength and reflexes improve post exercise
Commonly a paraneoplastic phenomenon associated with small cell lung cancer
Reflexes are reduced but improve post exercise, proximal muscle weakness
Ataxia, orthostatic hypotension, impaired sweating, dry mouth, incontinence.
Bloods: Voltage gated calcium channel antibodies
Imaging: Chest X-Ray and CT chest to look for lung cancer
Special tests: Nerve conduction studies and repetitive nerve stimulation show
an increase in compound muscle action potentials after voluntaryexercise..
Medical: Acetylcholine esterase inhibitors, corticosteroids, intravenous
immunoglobulin and plasma exchange
Surgical: Tumour removal
Dependent on prognosis of underlying cancer
Certain medications can cause deterioration in symptoms