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Pathology
Nephrotic Syndrome in which only some of the glomeruli are affected in a region of the glomerulus leading to renal scarring.
Aetiology
Primary: Idiopathic
Secondary: IgA nephropathy, Obesity, Heroin use, HIV, ureteric reflux
Signs
Marked pitting oedema, ascites and pleural effusions
Symptoms
Swollen legs, weight gain, lethargy, shortness of breath.
Investigations
Bloods: FBC, U&E, LFT’s, lipid profile glucose, myeloma screen, ANA
MSU: Urine dipstick and protein: creatinine ratio
Renal Biopsy: Partially sclerosed glomeruli
Treatment
Medical: Steroid therapy, immunosuppression
Prognosis
Majority develop renal failure within 10 years.
Renal failure
Key Facts
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Key Images
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Key References
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