Activation of the haemostatic system within the intravascular system resulting in widespread deposition of fibrin, activation of platelets and consumption of coagulation factors

Tissue Damage, Burns, Malignancy, Complications Of Pregnancy, Infection, 

Immunological Reactions, Toxins, Liver Disease

Bloods: Clotting screen shows prolonged PT, APPT, thrombin time and 

decreased fibrinogen, raised D-Dimer.

Blood Film: Red blood cell fragmentation

Medical:  Treat underlying cause, Transfusion of platelets, fresh frozen plasma, 

cryoprecipitate and red blood cells

Mortality greater than 80% in severe cases

Renal failure, major haemorrhage