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Pathology
Reduction in some or all of the pituitary hormones.
Aetiology
Congenital
Malignancy: Non-functioning adenoma
Vascular: Haemorrhage or infarction
Infection: TB and Syphilis
Inflammation
Post-irradiation
Traumatic brain injury
Signs
See specific hormone deficiencies e.g. hypothyroidism, hypogonadism
Symptoms
See specific hormone deficiencies e.g. hypothyroidism, hypogonadism
Investigations
Bloods: Pituitary profile.
Imaging: MRI pituitary
Special Tests: Humphrey’s field test, short synacthen test, insulin tolerance test
Treatment
Medical: Replacement of secondary hormones (e.g. thyroid, adrenal or gonadal).
Growth hormone replacement until full growth potential
Surgical: Trans-sphenoidal surgery
Prognosis
Normal life expectancy following adequate treatment
Poor quality of life, sub-fertility, increased cardiovascular morbidity and mortality, osteoporosis
Key Facts
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Key Images
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Key References
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