ron is deposited in liver, myocardium, pituitary and pancreas resulting in abnormal liver function tests, heart failure, pituitary failure and diabetes mellitus

Autosomal recessive genetic condition where mutations in the HFE gene causes excess iron absorption resulting in iron overload

Signs of chronic liver disease, signs of congestive cardiac failure, signs of hypogonadism, “bronze” diabetes (skin pigmentation from iron deposition and increased melanin)

Symptoms of cirrhosis, shortness of breath, peripheral oedema, polydipsia, polyuria, arthropathy 

Bloods: Very high ferritin and increased transferrin saturation 

Liver Biopsy: Iron overload 

HFE Gene Analysis: C282Y, H63D

Medical: Regular venesection or iron chelation 

Degree of liver damage is decisive of prognosis